New, large-scale research study to focus on microbiome and severe infections in infants.
WILMINGTON, Del., April 25, 2019 – It is estimated that nearly 3 million newborns and 1.2 million children suffer from sepsis globally each year, with limited effective forms of prevention currently available. To help combat this, DuPont Nutrition & Health (DuPont), the global leader in probiotics, will provide clinical trial probiotic and prebiotic products to the Centre for Global Child Health at The Hospital for Sick Children (SickKids) in Toronto for its research on the effects of probiotics on sepsis in infants.
DuPont was selected by scientists at SickKids to provide probiotics for a new, large-scale research study in Bangladesh, which will focus on the microbiome and severe infections in infants. The research is funded by a grant from the Bill & Melinda Gates Foundation and will be conducted in collaboration with the International Centre for Diarrheal Disease Research, Bangladesh and the Child Health Research Foundation, both based in Dhaka, Bangladesh.
“Sepsis continues to be a leading cause of newborn deaths, with infants in developing countries being disproportionately impacted,” said Matthias Heinzel, President, DuPont Nutrition & Health. “The current body of research shows that a probiotic/prebiotic blend is associated with a significant reduction in sepsis in infants, which is why we’re excited to supply them for this study.”
DuPont will offer its scientific expertise with a comprehensive analysis of the safety and characteristics of the probiotic strain used in the clinical study. DuPont also will develop a validated molecular method for specific detection of the strain. This will support clinical research aimed at determining if a precise probiotic/prebiotic combination can effectively colonize an infant’s developing microbiome, reduce the incidence of sepsis, and improve other health outcomes in early life.
The study comes in the wake of a previous clinical trial in rural India, the largest infant trial to date, which showed promise in reducing the risk of neonatal sepsis using the same combination of probiotic and prebiotic2. That trial, which did not involve DuPont or investigators from SickKids or its collaborators, also showed a significant reduction in lower respiratory tract infections. The findings suggested a potential beneficial effect on the development of infants’ immune systems. This same probiotic strain also has been demonstrated to increase colonization of beneficial bacteria in infants.
“We are honored to be able to provide our probiotic expertise for this important research,” said Buffy Stahl, Global Business Development Leader at DuPont Nutrition & Health, Probiotics. “This nutritional intervention holds great potential for supporting health in some of the most vulnerable people of all – babies.”
DuPont is committed to sustainability efforts in alignment with and support of the United Nations’ Sustainable Development Goals (SDG). This latest initiative with SickKids supports SDG 3 to ensure healthy lives and promote well-being for all ages. The goal aims to end preventable deaths of newborns and children under five years of age, more specifically to reduce neonatal mortality to 12 per 1,000 live births or lower and mortality of children under five to 25 per 1,000 live births or lower by 2030.
DuPont Nutrition & Health, a DowDuPont Specialty Products Division business unit, applies expert science to advance market-driven, healthy and sustainable solutions for the food, beverage, dietary supplement and pharmaceutical industries. We also use cutting-edge biotechnology across a range of markets to advance bio-based solutions to meet the needs of a growing population, while protecting our environment for future generations. We are innovative solvers who help our customers turn challenges into high-value business opportunities. For more information: www.dupontnutritionandhealth.com or www.biosciences.dupont.com.
DowDuPont Specialty Products, a division of DowDuPont (NYSE: DWDP), is a global innovation leader with technology-based materials, ingredients and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, building and construction, health and wellness, food and worker safety. DowDuPont intends to separate the Specialty Products Division, which will be called DuPont, into an independent, publicly traded company. More information can be found at www.dow-dupont.com.
 Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of pediatric and neonatal sepsis: a systematic review. The Lancet Respiratory medicine 2018; 6(3): 223-30
 Panigrahi et al., A randomized synbiotic trial to prevent sepsis among infants in rural India, Nature, volume 548, pages 407–412, 24 August 2017
 Chandel DS, Perez-Munoz ME, Fang Y et al Changes in the Gut Microbiota After Early Administration of Oral Synbiotics to Young Infants in India. Journal of Pediatric Gastroenterology and Nutrition Volume 65, Number 2, August 2017