Multidisciplinary Research Shows the Impact of Litesse® Fiber on Gut Microbiota and Lipid Metabolism in Mice

NEW YORK — Mar 15, 2021 — Continuing their leading research in the field of nutrition and health, IFF (formerly DuPont Nutrition & Biosciences) researchers, in collaboration with researchers from Afekta Technologies Ltd., Finland, and the University of Oulu, Finland, recently released the findings of their latest study on the health effects of Litesse® polydextrose, a soluble fiber with prebiotic properties.

As reported previously (Raza et al. 2017), Litesse® was found to alter the gut microbiota, and to reduce fasting triglycerides and total cholesterol plasma levels in mice being fed a Western diet - a diet characterized by a high intake of saturated fats and sucrose, and a low intake of fiber. This new study builds upon existing research, to help further understand the mechanisms of action that Litesse® has at the molecular level.

‘‘The previous findings were so interesting that we wanted to explore in more detail what is behind these positive changes in metabolism and microbiota,’’ commented Ph.Lic. Markku Saarinen, senior scientist, IFF. “Thus, we extended the focus of the previous research to a molecular level.’’ The study examined blood and tissue samples from the mice fed a Western diet, with or without oral administration of Litesse® polydextrose. Metabolomic analyses of these tissue samples were conducted and revealed significant differences between mice fed with polydextrose and the mice in the control group.

‘’Metabolomic analytics are increasingly being used in food and nutrition research and, when investigating research questions related to the function of gut microbiota. With metabolomics, it is possible to explore the conversion products made by gut microbiota from dietary components, and examine what kind of metabolic alterations they evoke in the circulation and potential target tissues,’’ added Dr. Olli Kärkkäinen, CEO, Afekta Technologies Ltd.

The results showed that Litesse® polydextrose caused differential metabolite patterns in blood and adipose tissues. It also demonstrated that one-carbon metabolism, bile acid and tryptophan metabolism were associated with the hypolipidemic effects observed in the mice receiving polydextrose. The inclusion of polydextrose in the diet may have also altered the absorption of other dietary components, resulting in the hypolipidemic effect. ’’While there are many dietary fibers on the market today, not all fibers act in the same way. Our study strongly supports this, which is why further investigation on whether the positive changes in lipid metabolism are also observed in humans is warranted,’’ concluded Dr. Heli Anglenius, senior scientist, IFF. 

You can read more about this study at


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