DuPont Introduces HOWARU® Calm, a New Probiotic Shown to Reduce Perceived Stress

Product helps adults manage the psychological response to perceived stress, promoting mental well-being and a relaxed state of mind

MADISON, WI., Jan. 12, 2021 DuPont Nutrition & Biosciences today launched HOWARU® Calm, a probiotic aimed at helping dietary supplement manufacturers decrease the cycle of consumer stress.

Surveys suggest 65 percent of adults worldwide indicate stress is a regular part of their daily lives[i].  Prolonged stress can negatively affect mood, sleep and digestive health.

HOWARU® Calm is the most recent addition to DuPont’s comprehensive HOWARU® portfolio and is shown to manage the psychological response to perceived stress.

“Too much stress, or daily chronic stress has become more prevalent in today’s society and can seriously impact our mental and physical well-being and overall health,” said Dr. Elaine Patterson, senior R&D scientist, DuPont Nutrition & Biosciences. “Over the last few years, we have been investigating the links between the gut microbiota and brain health —the so-called microbiota-gut-brain axis. During these investigations, our focus was on discovering a natural probiotic solution targeting brain health, more specifically mood, stress and anxiety. We are proud to finally share the fruits of our innovation and have developed a product that helps consumers target stress at the source so they can prioritize both their mental and physical health.”

Ahead of bringing HOWARU® Calm to market, the product’s featured strain – L. paracasei Lpc-37®, was scrupulously tested to ensure its quality, efficacy and performance. During a recent clinical study, participants took Lpc-37® daily for five weeks before undergoing an acute stress test — the Trier Social Stress Test – considered the most valid and reliable laboratory protocol for inducing stress in humans in a clinical setting. Researchers measured participants’ mood, stress and anxiety levels in response to the five-week intervention with Lpc-37®, their perceived and physiological response to the acute stress test at the end of the study, and their overall mood, health and well-being throughout the study, and compared the results to a placebo group. They found that those participants taking Lpc-37® reported a significant reduction in perceived stress following five-weeks of intervention.

“In the last five years, the industry has seen a 34 percent global increase of new probiotic supplements that help stabilize mood and combat stress, as consumers have begun to recognize the critical impact the gut has on the brain,” said Stephanie Udell, global marketing leader, DuPont Nutrition & Biosciences. “By launching HOWARU® Calm, we’re allowing dietary supplement manufacturers to develop an efficacious end-product that satisfies market demand for probiotic supplements aimed at reducing stress and promoting mental well-being.”

HOWARU® Calm can be added to existing dietary supplement products or used to create new ones. In addition, HOWARU® Calm can be formulated into innovative food and beverage products sure to meet the increasing consumer demand for alternative probiotic formats.

To learn more about HOWARU® Calm and how it can be incorporated into existing portfolio, visit

About DuPont Nutrition & Biosciences
DuPont Nutrition & Biosciences applies expert science to advance market-driven, healthy and sustainable solutions for the food, beverage, dietary supplement and pharmaceutical industries. We also use cutting-edge biotechnology across a range of markets to advance bio-based solutions to meet the needs of a growing population, while protecting our environment for future generations. We are innovative solvers who help our customers turn challenges into high-value business opportunities. For more information:

About DuPont
DuPont (NYSE: DD) is a global innovation leader with technology-based materials, ingredients and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, construction, water, health and wellness, food, and worker safety. More information can be found at Investors can access information included on the Investor Relations section of the website at

[i] Multi-sponsor Surveys, Inc. / 2018 Study of Energy Needs & Solutions.               

For further information contact:
Mariah Saerndahl



Get Started

DuPont cares about your privacy. Your personal information (name, email, phone number and other contact data) will be stored in chosen customer systems primarily hosted in the United States. This information will be used by DuPont, its affiliates, partners, and selected third parties in other countries to provide you with the product or service information requested. To learn more, please visit By providing your personal information, you agree to the terms and conditions of this Privacy Statement.

/content/dupont/amer/us/en/nutrition-biosciences/contact-us.html /content/dupont/amer/us/en/nutrition-biosciences/references/corporate-contact-us.html /content/dupont/amer/us/en/nutrition-biosciences/references/subscribe.html