DuPont Demonstrates Leadership and Innovation in the Field of Early Life Nutrition

New studies and regulatory filings propel DuPont to the forefront of human milk oligosaccharides commercialization

KANTVIK, Finland, July 7, 2020 – DuPont Nutrition & Biosciences recently released the findings of a first-time new study showing the effects Care4U™ 2’-FL had on dental caries-associated bacterium Streptococcus mutans.

“Human milk is known to contain factors that protect against caries, so we were interested to know how HMOs, and especially 2’-FL, affect S. mutans, one of the most studied bacteria related to dental caries, said Johanna Hirvonen Ph.D., Senior Scientist, DuPont Nutrition & Biosciences. “This study was a collaboration between University of Turku, Institute of Dentistry and DuPont Nutrition & Biosciences. We evaluated the ability of S. mutans to grow on 2’-fucosyllactose (2’-FL) in comparison to galacto-oligosaccharides (GOS), lactose, and xylitol. The effects of 2’-FL, GOS, lactose, and xylitol on adhesion properties of S. mutans were also evaluated. While this study was done under in vitro conditions, it showed the differences between the studied carbohydrates, especially in S. mutans growth.” 

“Though it is known that S. mutans can metabolize many carbon sources, we found that S. mutans was unable to grow on 2’-FL, while it grew well on GOS and lactose. Xylitol, as known before, reduced the growth of S. mutans,” added Krista Salli, M.Sc., Scientist, DuPont Nutrition & Biosciences.Thus, the data suggests that addition of 2’-FL to infant formula would not support the growth of S. mutans.  The results highlight the selectivity of 2’-FL consumption by oral bacteria,”

Adhesion to tooth surfaces is the first requirement for a biofilm—dental plaque–formation, 2’-FL decreased the adhesive properties of some of the studied S. mutans strains. In infancy, oral microbiota develops, and delays colonization of potentially pathogenic bacteria is vital. DuPont is expanding on this line of research with other oral bacteria and additional HMOs.

For more information on the study: DOI: https://doi.org/10.1017/S0007114520001956

Regulatory Update: Our New HMO, 3-FL

In addition to the exciting research being conducted on Care4U™ 2’-FL, DuPont recognizes the need to continue to bridge the nutritional gap in infant formula. The next most abundant HMO in human milk after 2’-FL, and soon to be commercialized by DuPont, is 3-fucosyllactose (3-FL). This HMO is present in human milk of all mothers and is unique in that levels have been reported to increase during lactation, contrary to 2’FL that decreases during lactation. Initial in vitro research demonstrates that in addition to being bifidogenic, this HMO is effective in reducing colon motor contractions and inhibits bacterial adhesion. Further research is needed to confirm clinical benefits.  

A scientific expert panel has recently concluded that DuPont’s newest HMO, Care4U™ 3-FL HMO, is Generally Recognized as Safe (GRAS) for use in various applications including formulas intended for infants and young children, other foods and beverages consumed by toddlers under 3 years as well as foods for the general population. The FDA has been notified of DuPont’s GRAS conclusion. In October 2019, DuPont submitted a novel food application with the European Food Safety Authority (EFSA) to obtain market authorization in the EU for 3-FL. These regulatory developments demonstrate the steady progression of DuPont’s investment and commitment to HMOs.

Paving the Path Forward: New Applications

As we continue to move forward with our new research and commercialization of novel ingredients in Early Life Nutrition, we need to be assured that there is a method for the robust quantification of these two compounds in the applications that they are used in. Recent published research by DuPont demonstrated that a high-performance liquid chromatography (HPLC) method is available that allows researchers and formulators to analyze the amount of 2’-FL and 3-FL in a range of food products and quickly and efficiently perform shelf-life studies in these food applications. This is a major step forward for manufacturers interested in to developing high quality, efficacious nutritional products for early life nutrition and beyond.

For more information on the findings: https://pubmed.ncbi.nlm.nih.gov/31968133/

“At DuPont, we’re excited to continue our innovation in Early Life Nutrition with HMOs and probiotics to support healthy growth and development during infancy,” stated Ratna Mukherjea, Ph.D., technical fellow and global research and development leader, Human Milk Oligosaccharides, DuPont Nutrition & Biosciences. “Further, the health benefits of HMOs and probiotics can be extended beyond infant nutrition to that of adult nutrition and dietary supplements.”

About DuPont Nutrition & Biosciences
DuPont Nutrition & Biosciences applies expert science to advance market-driven, healthy and sustainable solutions for the food, beverage, dietary supplement and pharmaceutical industries. We also use cutting-edge biotechnology across a range of markets to advance bio-based solutions to meet the needs of a growing population, while protecting our environment for future generations. We are innovative solvers who help our customers turn challenges into high-value business opportunities. For more information: www.dupontnutritionandbiosciences.com or www.biosciences.dupont.com.

About DuPont

DuPont (NYSE: DD) is a global innovation leader with technology-based materials, ingredients and solutions that help transform industries and everyday life. Our employees apply diverse science and expertise to help customers advance their best ideas and deliver essential innovations in key markets including electronics, transportation, construction, water, health and wellness, food, and worker safety. More information can be found at www.dupont.com.

For further information contact:
Mariah Saerndahl

715-210-2509

Mariah.Saerndahl@dupont.com

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