Dow Pharma Solutions a business unit of DowDuPont Speciality Division is proud to be present at Making Pharmaceuticals Exhibition & Conference, Booth 430, April 24-25, Ricoh Arena in Coventry, UK.
Making Pharmaceuticals has one of the largest free to attend pharmaceutical conferences in the UK, with five rooms and over 35 hours of free to access pharmaceutical content.
Please do not miss the opportunity to be in the audience to hear:
- Dr. Meinolf Brackhagen, Senior TS&D Scientist, presentation at 09:30 on April 24 in room B entitled: Expanded Design Space in Hot Melt Extrusion with High Productivity Hypromellose Acetate Succinate.
To date, there are few excipients that have been specifically developed for spray drying and hot melt extrusion applications. The excipients used in this application space were typically developed for other applications such as enteric coatings and are not optimized for the spray drying or hot melt extrusion process. The presentation will covers results from a study comparing AFFINISOL™ High Productivity HPMCAS, a new grade of HPMCAS designed specifically to improve processability in spray drying and hot melt extrusion, to standard (commercially available) HPMCAS. The High Productivity HPMCAS has reduced melt viscosity compared to standard commercial HPMCAS, resulting in lower die pressure and reduced torque and free acid generation. It was found that the HPMCAS polymers were easily extrudable at temperatures above 150°C (standard HPMCAS) and 135°C (HP HPMCAS). Minimized generation of free acids was observed at moderately high temperatures (150-170°C) under low shear/low residence time conditions (150-200 rpm, 400-500 g/h). It was as well found that under same conditions, HP HPMCAS allowed for extrusion with significantly lower die pressure and considerably lower drive load and free acid levels.
- Dr Matthias Knarr, Research Scientist, presentation at 2 pm on April 25 in room B entitled: Analyzing Thermo-Sensitive Properties of METHOCEL™ to Predict Modified-Release Performance.
DuPont will have experts present throughout the event, so please do take this opportunity to connect us.
Find out more about the event here.