The state describing the interaction between nutrition, microbiome and gut and immune function



An introduction to nutribiosis - The state describing the interaction between nutrition, microbiome and gut and immune function

These three functional areas of animal health – nutrition, microbiome and gut and immune function – are not new to animal producers. However, the industry has traditionally been looking at them in a siloed way. At Danisco Animal Nutrition we believe in a more holistic approach. The understanding of how they interact and impact each other is crucial, and is what makes Nutribiosis unique compared with other gut health concepts in the market.


The Three Components of Nutribiosis


  • Nutrition

Ensuring that the animal has all the nutrients needed to reach its full potential. It is also important to either limit the amount of undigested nutrients or control the types of undigested nutrients that reach the terminal ileum, so that we don’t provide substrates on which the non-beneficial bacterial populations can feed and thrive.


  • Microbiome

The diversity of microorganism is key: where beneficial bacteria outnumber non-beneficial bacteria, keeping possible opportunistic pathogens under control. This avoids the occurrence of sub-clinical and clinical disease challenges that would otherwise reduce overall performance and profitability.


  • Gut & Immune Function

They are vital to allow animals to maximize nutrient absorption and deal with challenges when they occur - whether they are bacterial, viral or environmental.  Any immune response mounted by the animal uses energy and can negatively impact growth if the immune response is sustained or uncontrolled.


A holistic view

We believe that taking a holistic view, which considers how everything that is fed to an animal combines and interacts in the GIT, is the way forward. It’s the driving force behind nutribiosis – an approach developed to provide new insights and help animal producers to:

  • Make more profitable decisions
  • Improve animal performance
  • Improve animal welfare
  • Improve gut health

‘Nutribiosis has become an integrated part of the innovation work we are doing’

Danisco Animal Nutrition Innovation Director Dr. Leon Marchal explains how we are integrating nutribiosis when developing solutions for the animal production industry and examples of favorable and unfavorable states in farms.


Nutribiosis, an integrated part of the innovation work

The state of Nutribiosis

Nutribiosis is a state - and as such, it can be favorable or unfavorable. Achieving and maintaining the optimum balance between these three components - known as a “favorable nutribiotic state” - is crucial for good GIT health in an animal, which in turn helps to maximise performance.  However, the fragile environment of the GIT means that it is susceptible to a range of external factors, such as climate, environment or disease, which can throw this trinity off-balance.

To explain the value of Nutribiosis it is helpful to look at it in the context of a number of examples: where different interactions between its three pillars lead to a “favorable” or “unfavorable” nutribiotic state, and a corresponding positive or negative outcome in the animal.


Favorable Nutribiotic State:

Good Gut Health & Optimal Performance

Poultry: The use of Syncra® AVI, our unique enzyme and multi-strain probiotic solution, in feed formulation positively influences the nutribiotic state - even for low challenge birds. This includes improving intestinal integrity and gut health, enhancing digestibility of starch, fat and protein as well as increasing beneficial bacteria populations versus non-beneficial equivalents

Swine: Our adaptive protease and probiotic solution, Syncra® SWI, has been shown to improve key interactions within the GIT in grower and finisher pigs. It works to improve gut barrier strength through tighter junctions, enhances protein digestibility, amino acid utilisation and fibre bound nutrient release, as well as positively impacting the microbiome function in a number of important ways

Phytase: Axtra® PHY, the fastest-acting phytase, breaks down phytate quickly before it binds the protein, avoiding the anti-nutritive effect and improving nutrient uptake for a healthier, better functioning gut.  Ultimately, this results in less undigested protein reaching the caeca or hind gut, reducing protein fermentation and potentially reducing ammonia production, contributing to a favorable nutribiotic state


Unfavorable Nutribiotic State:

Poor Gut Health & Suboptimal Performance

Poultry: Necrotic enteritis is a condition which arises from a combination of an intestinal challenge - such as coccidiosis - and an overload of nutrients in the latter part of the intestinal tract. The opportunistic pathogen, C. perfringens, thrives on the high levels of undigested protein that are present; causing intestinal damage and negatively impacting gut function

Swine: High protein diets are associated with swine dysentery. This is due to its low nutrient digestibility which, when combined with poor management practices, can cause increased prevalence of Brachyspira hyodysentariae. This spirochaetal bacterium induces excessive inflammation and necrosis of the epithelial surface of the caecum and colon (large intestine) and diarrhoea

Phytate: phytate binds protein in the upper GIT, making it unavailable to the animal, resulting in increased acid and pepsin production in the stomach.  This increases acidity so as the stomach empties it can damage the gut absorptive surface and requires more buffering through release of sodium bicarbonate.   The increased demand for sodium negatively effects gut function by depleting sodium levels in cells, reducing the functionality of the sodium pumps required for key nutrient such as glucose and amino acids absorption


Pioneering Approach

As leaders in both enzyme and gut health technologies, we aim to realise the full potential of Nutribiosis by leveraging our extensive expertise encompassing:



Microbiome profiling research in Brazil

Results from microbiome profiling research done in Brazil demonstrates the microbiome diversity within geographic

The state-of-the-art microbiology lab

The understanding of the microbiome is key when replacing or removing antibiotics from production systems. In

Validation of new probiotics

In-vitro results in isolation do not give the full picture of a challenge. Results need to be validated in the animal and in the field.


Multidisciplinary approach to understand the microbiome

The microbiology lab is one piece of the puzzle. In order to understand the microbiome and bring effective solution to

Understanding dermatitis through microbiome profiling

Dermatitis is a multi-faced disease. Therefore it is important to understand the critical factors leading to it in order to

A nutribiotic approach to Necrotic enteritis

Dr. Franco Mussini discuss how from a formulation approach we reduce the risk of birds breaking with Necrotic entiritis,


How nutribiosis influences nutrition

Dr. Janet Remus talks about how nutribiosis - the connection between microbiome, gut & immune function and nutrition -

DuPont Microbiome Platform

Dr. Andrew Morgan talks about how Nutrition & Biosciences led the development of the first generation of microbiome solutions and is


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