These three functional areas of animal health – nutrition, microbiome and gut and immune function – are not new to animal producers. However, the industry has traditionally been looking at them in a siloed way. At DuPont Animal Nutrition we believe in a more holistic approach. The understanding of how they interact and impact each other is crucial, and is what makes Nutribiosis unique compared with other gut health concepts in the market.
We believe that taking a holistic view, which considers how everything that is fed to an animal combines and interacts in the GIT, is the way forward. It’s the driving force behind nutribiosis – an approach developed to provide new insights and help animal producers to:
Animal Nutrition Innovation Director Dr. Leon Marchal explains how we are integrating nutribiosis when developing solutions for the animal production industry and examples of favorable and unfavorable states in farms.
Nutribiosis is a state - and as such, it can be favorable or unfavorable. Achieving and maintaining the optimum balance between these three components - known as a “favorable nutribiotic state” - is crucial for good GIT health in an animal, which in turn helps to maximise performance. However, the fragile environment of the GIT means that it is susceptible to a range of external factors, such as climate, environment or disease, which can throw this trinity off-balance.
To explain the value of Nutribiosis it is helpful to look at it in the context of a number of examples: where different interactions between its three pillars lead to a “favorable” or “unfavorable” nutribiotic state, and a corresponding positive or negative outcome in the animal.
Poultry: The use of Syncra® AVI, our unique enzyme and multi-strain probiotic solution, in feed formulation positively influences the nutribiotic state - even for low challenge birds. This includes improving intestinal integrity and gut health, enhancing digestibility of starch, fat and protein as well as increasing beneficial bacteria populations versus non-beneficial equivalents
Swine: Our adaptive protease and probiotic solution, Syncra® SWI, has been shown to improve key interactions within the GIT in grower and finisher pigs. It works to improve gut barrier strength through tighter junctions, enhances protein digestibility, amino acid utilisation and fibre bound nutrient release, as well as positively impacting the microbiome function in a number of important ways
Phytase: Axtra® PHY, the fastest-acting phytase, breaks down phytate quickly before it binds the protein, avoiding the anti-nutritive effect and improving nutrient uptake for a healthier, better functioning gut. Ultimately, this results in less undigested protein reaching the caeca or hind gut, reducing protein fermentation and potentially reducing ammonia production, contributing to a favorable nutribiotic state
Poultry: Necrotic enteritis is a condition which arises from a combination of an intestinal challenge - such as coccidiosis - and an overload of nutrients in the latter part of the intestinal tract. The opportunistic pathogen, C. perfringens, thrives on the high levels of undigested protein that are present; causing intestinal damage and negatively impacting gut function
Swine: High protein diets are associated with swine dysentery. This is due to its low nutrient digestibility which, when combined with poor management practices, can cause increased prevalence of Brachyspira hyodysentariae. This spirochaetal bacterium induces excessive inflammation and necrosis of the epithelial surface of the caecum and colon (large intestine) and diarrhoea
Phytate: phytate binds protein in the upper GIT, making it unavailable to the animal, resulting in increased acid and pepsin production in the stomach. This increases acidity so as the stomach empties it can damage the gut absorptive surface and requires more buffering through release of sodium bicarbonate. The increased demand for sodium negatively effects gut function by depleting sodium levels in cells, reducing the functionality of the sodium pumps required for key nutrient such as glucose and amino acids absorption
As leaders in both enzyme and gut health technologies, we aim to realise the full potential of Nutribiosis by leveraging our extensive expertise encompassing: